In the recent past, almost all scientists and engineers performed experiments by changing one variable at a time (while holding all others constant). Depending upon what the system or experiment is, this may not a bad method, especially if one variable is causing most of the change with the system. However, there are many instances where there is not one main variable that is causing the change in the system — but it is the interaction between one or more variables. DOE will tell you the important factors or interactions to change or experiment with.